How Harold Got His Building, and Several Other Things

How Women Got Their Curves and Other Just-So Stories

tail is a little variable. If you want a third-generation cephalosporin, for example, you’re in luck, as the antibiotics are well organized. Looking for an SSRI? It’s somewhere in the antidepressant section. Antihistamines are also a single group. You must flip to the main entries should you forget whether a drug is for a runny nose or gastritis. The book does seem to have an internal medicine ...

When man got his mtDNA deletions?

Somatic mtDNA mutations and deletions in particular are known to clonally expand within cells, eventually reaching detrimental intracellular concentrations. The possibility that clonal expansion is a slow process taking a lifetime had prompted an idea that founder mutations of mutant clones that cause mitochondrial dysfunction in the aged tissue might have originated early in life. If, converse...

How the Pufferfish Got His Spikes: Neurotoxicity in Sodium Channel Blockers

Tropes and Other Things

Our day-today experience of the world regularly brings us into contact with middle-sized objects such as apples, dogs, and other human beings. These objects possess observable properties, properties that are available or accessible to the unaided senses, such as redness and roundness, as well as properties that are not so available, such as chemical ones. Both of these kinds of properties serve...

Response to: ‘when man got his mtDNA deletions?’

Sean D. Taylor, Jesse J. Salk and Jason H. Bielas Translational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, Seattle, WA 98109, USA Department of Medicine, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA 98195, USA Department of Pathology, University of Washington Medical Center, 1959 NE Pacific St, Seattl...